The purpose of this research is to investigate the factors affecting the formation of leading schools, so that it can be used in Iran's education. For this purpose, first, according to the research background and theoretical foundations, a conceptual framework was presented in the field of the components of an efficient and progressive school. Due to the nature of the subject, this research is an applied and developmental research and its method is of a mixed type, and includes quantitative and qualitative methods. According to the obtained information, the statistical population is about 3000 people. The sample size is estimated to be 344 people using Morgan's table. Stratified sampling method was used for sampling in this research, and 84 managers and 260 teachers participated in this study. The tool of this research is a researcher-made questionnaire. To analyze the data and answer the research questions, the correlation coefficient test and factor analysis were used. The results of the research showed that the components of management and leadership, research factors, educational factors, human resources, budget and infrastructure, technology and equipment are the main components of the formation of leading schools, and the component of educational factors has the largest contribution.

Zinc has an important role in skin health and its deficiency reduces immunity to evaluate levels of zinc in squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) of skin, we studied 44 BCC and 38 SCC cases together with 33 controls. Blood samples were taken and after separation of serum, levels of zinc, albumin and total protein were measured by atomic absorption albumin kit and reflectometer consecutively. Serum globulin levels were estimated by subtracting albumin from total protein levels. Zinc levels were significantly lower in cancer cases than control (P<0.001). Mean serum albumin of BCC cases was significantly more than controls (P<0.01), but in BCC cases was not significantly different. Significant correlations were seen between levels of serum zinc and albumin of SCC (r=0.507, P<0.01) and BCC(r=0.43, P<0.01) patients and controls(r=0.35,P<0.01). Mean globulin levels in cancer cases were significantly lower than control group (P<0.01).We concluded that serum zinc and globulin levels decrease in BCC and SCC of skin.

Milk thistle (Silybum marianum (L.) Gaertn) belonging to the Asteraceae family and known for its valuable secondary metabolite, silymarin. In order to get the cell suspension culture of Silybum marianum, the combination of 2,4-D and BAP hormones each with five different concentrations (0, 0.1, 1, 2 and 5 mg/L) and 3 different seedling explants (cotyledon, hypocotyl and root) was used to callus formation. High-quality callus was observed in eight different of hormone-explant combinations. Successful cell suspension culture was achieved only by using callus created from cotyledon explants treated with 0.1 mg/L 2,4-D and 5 mg/L BAP. Furthermore, the study examined the effects of 2% and 4% Serendipita indica cell wall extract as an elicitor on silymarin production in cell suspension culture at three different inoculation times (24, 48, and 72 h). After 48 h of inoculation with 2% fungal extract, the highest level of silymarin (199 ppm) was observed, which was significantly different from the control (46 ppm). The silymarin content of cells increased over time through elicitation with 4% fungal elicitor, while no similar pattern was observed with 2% fungal extract. Based on the results, the cell wall of S. indica can significantly enhance the amount of SLM in the cell suspension culture of S. marianum.

Background: It is demonstrated that c-Kit (receptor of stem cell factor) mRNA is expressed in late 2-cell stage to the expanded and hatched blastocyst and the stem cell factor (SCF) transcript is detected in the oviduct and uterus. The aim of this study was to investigate the effect of different doses of SCF on mouse 2-cell embryo developmentin vitro.Materials and Methods: 4-6 weeks old female mice were superovulated by i.p. injection of 7.5 IU PMSG and 46-48 hours later 7.5 IU hCG and caged overnight with males. 2-cell stage embryos were collected from oviducts and cultured in T6 medium supplemented with 0, 1, 20 and 50 ng/ml SCF to blastocyst stage then the number of blastocysts, hatching/ hatched and survived blastocysts was assessed.Results: The proportion of 2-cell embryos which developed to the blastocyst stage in group of 50 ng/ml SCF were significantly higher than control group (p<0.05).There was no difference in blastocyst formation between 1 and 20 ng/ml SCF and control groups (p>0.05). Hatching rate and blastocyst survival among control and treatment groups was not significant (p>0.05).Conclusion: Culture of mouse 2-cell embryos in the presence of SCF has beneficial effects on the rate of blastocyst formation.

Background and Objective: Bordetella pertussis is a gram-negative cocobacilli bacterium and etiologic agent of whooping cough that in recent years, the number of its cases is on the rise. The ability of biofilm production helps this bacterium in interference with host immune system, severity of illness and antibiotic sensitivity. Thus, due to the importance of this factor, in this investigation, we tested the ability of Bordetella pertussis isolates in biofilm formation.Materials and Methods: Nasopharyngeal samples were collected from persons who suspected whooping cough from throughout of Iran from 2014 to 2016 and were transferred to pertussis reference laboratory in Pasteur Institute of Iran. The bacterium in question was isolated by culture so that finally we had 20 positive samples. At the end, we performed in vitro biofilm formation test for isolated strains.Results: All of the 20 clinical samples of Bordetella pertussis which in this study were examined could form biofilm and their final OD became between 0.606 and 1.212, the power of the biofilm made by them was intermediate. Conclusion: Findings of this study was similar to researches conducted by other researchers, which showed the ability of the strains of Bordetella pertussis to form biofilm and to create adverse effects on the host for example antibiotic resistance, illness severity, and so on. Thus, considering the importance of this issue, more and broader researches are needed in this area.

Basal cell carcinoma is the, most common skin cancer that has nodular, superficial, micronodular, Morpheaform, pigmented, metatypical and fibroepithelioma of Pinkus subtypes. In this report, we evaluated the efficacy of cryosurgery with liquid nitrogen for basal cell carcinoma in three patients. The response was good and patients were followed regularly. There were no recurrences after 25 months follow-up. This method is fast and appropriate for certain types of basal cell carcinomas.      

In this study a 31 y/o woman who was housewife, came from Mazandaran and lived in Behshahr is presented. Patient's complaints were diarrhea, bloating, abdominal pain and weight loss. Abdominal radiography showed loop dilatation. In primary Para clinic assessments she had Alb: 2.8, Ca: 6.4, P: 2.3 and PTH: 201. Considering malabsorption in early evaluation, upper endoscopy was done. Intestinal folds were disappeared in second and third part of duodenum in endoscopic view and duodenal biopsy was done. Then pathological assessment revealed a large accumulation of intraepithelial lymphocytes and obvious villus atrophy that was accordant to celiac sprue. She was advised to be on gluten free diet. After about 1 month, She was referred because of sever lower extremities edema. Serum albumin was checked that was 2. Enlarged mesenteric lymph nodes were detected in sonography. Considering non- responding treatment, IHC staining of intestinal biopsy was performed with celiac sprue complication suspicion.Therefore the patient was referred to chemotherapy center with the diagnosis of T-cell lymphoma following celiac sprue. She was spent 6 course chemotherapy with CHOP regimen and radiotherapy.